Novel clock genes and principles

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Regarding 10 clock genetics, orthologous in turn yet not necessarily similar in function, are
known in mammals and Drosophila but various results suggest numerous remain to be determined.

A QTL study suggests 14 as-yet-unidentified loci that regulate period or phase in computer mice. Mutant displays have produced computer mice that lug mutations at heretofore un-described loci.

Crosses of people with similar clock buildings have a wide distribution of clock residential properties (i.e., duration, phase) suggesting incredibly complicated hereditary law. The most extreme stage mutant amongst the collection of clock mutant animals is the tau mutant hamster.

The mutation is in a casein kinase encoding genetics that customizes the core molecular responses loophole however is not itself a transcription element. The identification of brand-new clock genetics has been just one of the main driving forces in the field. Each new genetics contributes to our insight right into pathways and also connect with clock devices involved.

This Sub-Project suggests to identify novel clock genes and polymorphisms or clock principles in humans, mice and also Drosophila. This cross-species strategy enables us to maximize the advantages of discovery of variant genes in different organisms. At the same time it prepares the ground for useful experiments in these version organisms.

Sub-Project Leader: Prof. Martha Merrow, PhD, University of Groningen, Chronobiology

Members

  • Prof. Dr. Till Roenneberg, LMU Munich, Institute for Medical Psychology
  • Prof. Dr. Ralf Stanewsky, Queen Mary & Westfield University, School of Biological Sciences
  • Prof. Dr. Achim Kramer (Replacement Leader), Charit?, Achim Kramer Lab
  • Prof. Dr. Thomas Meitinger, GSF, Institute of Human Genetics
  • Prof. Dr. Andres Metspalu, Estonia Biocentre, Department of Biotechnology
  • Prof. Dr. Andrew Millar, University of Edinburgh, Institute of Molecular Plant Scientific Research
  • Prof. Dr. Ference Nagy, Biological Proving Ground, Institute of Plant Biology
  • Prof. Dr. Pat Nolan, Medical Research Council, Medical Research Study Council
  • Dr. Fran├žois Rouyer, CNRS, Institute de Neurobiologie Alfred Fessard
  • Dr. Konstantin Danilenko, Russian Academy of Medical Science, Institute of Internal Medicine
  • Dr. Emma Perfect, LUX Biotechnology

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